陈伟良教授简介

 

 

 

陈伟良,中山大学二级教授,一级主任医师, 博士生导师,国家重点临床专科(口腔颌面外科)学科带头人,中山大学颅颌面外科中心主任,中山大学孙逸仙纪念医院(附属第二医院)口腔科主任。广东省医学会颌面-头颈外科学分会前主任委员。国际口腔颌面外科协会会员和国际口腔癌协会会员。

1983年中山医科大学口腔医学系毕业,1987年中山医科大学高级英语班培训,1998年美国加州大学(UCLA)客座教授, 在美研修口腔颌面外科,2003年在澳大利亚皇家儿童医院研修颅颌面外科。2005年中山大学岭南(大学)学院高级工商管理班毕业,获h-EMBA学位。

自1983年中山医科大学口腔医学系毕业以来一直在中山大学孙逸仙纪念医院(附属第二医院)口腔颌面外科从事医疗、教学和科研工作。1990年晋升为讲师,主治医师;1995年破格晋升为副主任医师,1996年转评为副教授,硕士研究生导师;2000年晋升教授,主任医师。1994年至1997年任口腔科副主任,1997年至2000年任口腔科主任,2001年至2003年任中山大学颅颌面外科中心副主任兼中山二院南院副院长。2005年至2007年任中山大学颅颌面外科中心副主任兼附属第二医院口腔颌面外科主任。2007年竟聘上三级教授,2008年至今任中山大学颅颌面外科中心主任兼孙逸仙纪念医院口腔科主任,博士研究生导师。2011年作为口腔颌面外科学科带头人,主持申报国家重点临床专科(口腔颌面外科)获得成功,并带领口腔颌面外科团队开展工作。2012年,经国家卫计委严格审定并批准,主持第三类医疗技术-口腔颌面部肿瘤颅颌联合根治术和颅颌面畸形矫治术。2014年竟聘上二级教授,一级主任医师。

  对口腔颅颌面-头颈部良性(如颌骨囊肿,鳃裂囊肿,腮腺混合瘤,成釉细胞瘤等)和恶性肿瘤(舌癌,牙龈癌,颊癌,腭癌,舌根癌等口腔口咽癌和颌面颌骨肉瘤)在分子水平方面有深入的研究。在良恶性肿瘤手术治疗,软硬组织缺损修复以及中晚期口腔癌化学治疗、基因靶向治疗和免疫治疗等综合治疗;口腔颌面部脉管疾病-血管瘤,淋巴管瘤,脉管畸形的基础研究,治疗包括手术、超选择性栓塞、放射、硬化、核素和冷冻等综合治疗;口腔颌面部外伤骨折救治;口腔颌面部感染的治疗;口腔颌面部先天(唇腭裂和颌骨畸形)后天畸形(外伤疤痕和缺损)整复;颌骨前突或后缩畸形整复和口腔颅颌面痛症和神经精神疾病的诊断和治疗等有很深造诣。近年来,大力开展了内窥镜微创外科技术,颅底咽旁肿瘤以及侵犯颈动脉晚期头颈肿瘤和颈动脉体瘤治疗,取得非常理想疗效。

   国家重点临床专科(口腔颌面外科)学科带头人,发表学术论文100多篇,其80多篇被SCI收录,国际会议交流18篇。2003年在澳大利亚墨尔本获国际口腔癌协会颁发的优秀奖,并成为学术组成员。 系列研究《舌癌根治术后病者生存率和生存质量评估》 《口腔颌面头颈部大型组织缺损修复的系列研究》和《口腔颌面部血管瘤-脉管疾病综合治疗》 分别在2003年,2007年和2014年获广东省人民政府科技成果奖。 《口腔颌面部肿瘤颅颌联合根治术与颅面缺损的修复与重建》和《下牙槽神经外侧升支颌骨切开进路切除咽旁肿瘤及内窥镜辅助下经口腔切除咽部巨大肿瘤两种新技术》 分别获我院2012年2013年医疗新技术二等奖和一等奖。

   国际著名杂志Cancer, Cancer Biomarkers, Head & Neck,International Journal of Oral & Maxillofacial Surgery, Oral Oncology, World Journal of Surgical Oncology,Journal of Oral Pathology and Medicine, European Surgical Research, Clinical Anatomy, Saudi Medical Journal, European Surgical Research, International Journal of Otolaryngology, International Journal of Pediatric Otorhinolaryngology, Journal of Pediatric Surgery,Annals of Medical and Health Sciences Research, Indian Journal of Dental Research, Open Journal of Stomatology和中华医学杂志, Chinese Journal of Dental Research,中山大学学报(医科版)和中国口腔颌面外科杂志等国内外著名杂志的审稿专家,以及2011年版《中文核心期刊要目总览》评审专家。现任中国口腔颌面外科杂志和中国实用口腔科杂志编委。

1994年香港国际唇腭裂会议作学术报告;2003年和2005年分别在澳大利亚墨尔本举行的国际口腔癌学术会议和希腊雅典举行的国际口腔癌学术会议作学术报告;2005年赴美国加州大学伯克利分校、洛杉矶分校和斯坦福大学调研医药卫生管理及学术流;2007年和2009年分别在第一届世界口腔肿瘤大会(荷兰阿姆斯特丹)和第二届世界口腔肿瘤大会(加拿大大多伦多)作学术报告;2009年5月和2015年9月分别在第19届国际口腔颌面外科大会(上海)作学术报告和主持分会场学术活动和第22届国际口腔颌面外科大会(澳大利亚墨尔本)作学术报告。

2003年~2015年连续10多年主持国家级继续教育项目—《口腔颌面-头颈肿瘤预防和综合治疗高级研修班》,1998年至2016年指导口腔颌面外科硕士研究生40多名,指导博士后和博士生20多名。为我国培养一大批高级口腔颌面外科人才。

主持国家及省部级科研课题15项,包括国家自然科学基金课题—iNOS/NO在癌相关成纤维细胞促进舌鳞癌侵袭转移中的作用机制研究;广东省自然科学基金课题—癌相关成纤维细胞激活一氧化氮合酶信号促进舌鳞癌侵袭转移的作用机制研究和广州市科技计划项目—叶酸预防维甲酸诱导的小鼠腭裂的基因表达谱的的研究。

 

 

   陈伟良教授近年来以第一作者/通信作者在SCI期刊源上论文题录(可来函索取全文)

82. Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation. Br J Oral Maxillofac Surg. 2015 Dec 16. pii: S0266-4356(15)00706-8. doi: 10.1016/j.bjoms.2015.11.020.

81. Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1. Oral Oncol. 2015;51(12):1095-102.

80. Management of Carotid Body Tumor and Pseudoaneurysm After Blunt Dissection. J Craniofac Surg. J Craniofac Surg. 2015;26(2):477-480.

79. Comparison between an extended vertical lower trapezius island myocutaneous flap and a pectoralis major myocutaneous flap used for reconstruction in patients with recurrent oral and oropharyngeal cancer. Head Neck. 2014 Dec 22. doi: 10.1002/hed.23960.

78. Liquid nitrogen cryotherapy for lip mucous membrane venous malformation in infants. Pediatr Surg Int. 2015;31(3):283-5.

77. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1.Cancer Sci. 2014;105(10):1288-98.                       

76. Use of extended vertical lower trapezius island myocutaneous flaps to cover exposed reconstructive plates. J Oral Maxillofac Surg. 2014 ;72(10):2092.

75. Endoscopy-assisted transoral resection of large benign parapharyngeal space tumors. Br J Oral Maxillofac Surg. 2014 52(10):970-973.

74. Minimally Invasive Selective Neck Dissection: A Prospective Study of Endoscopically Assisted Dissection via a Small Submandibular Approach in cT1-2N 0 Oral Squamous Cell Carcinoma.Ann Surg Oncol. 2014;21(12):3876-81.

73. RECK overexpression reduces invasive ability in ameloblastoma cells. J Oral Pathol Med. 2014;43(8):613-8.

72. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma. J Oral Pathol Med. 2014;43(8):585-92.

71. Use of a folded reverse facial-submental artery submental island flap to reconstruct soft palate defects following cancer ablation. J Craniomaxillofac Surg. 2014;42(6):910-914.

70. Second salvage surgery with extended vertical lower trapezius island myocutaneous flap reconstruction for advanced re-recurrent oral and oropharyngeal squamous cell carcinoma. Int J Oral Maxillofac Surg. 2014;43(5):531-8. 

69. Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma. Br J Cancer. 2014;110(3):695-705. 

68. Reconstruction of through-and-through  oral cavity defects with folded extended vertical lower trapezius island myocutaneous flap. Br J Oral Maxillo facSurg. 2013;51(8):731-5.

67. The role of NEFL in cell growth and invasion in head and neck squamous cell carcinoma cell lines. J Oral Pathol Med. 2014;43(3):191-8.

66. Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells. J Oral Pathol Med. 2013;42(7):541-6. 

65. Surgical excision of sialoblastoma in the parotid gland in newborn. Int J Pediatr Otorhinolaryngol. 2013;77(8):1268-71.

64. Osteotomy in the vertical ramus outside the   mandibular foramen for tumours in the parapharyngeal space. J Craniomaxillofac Surg. J Craniomaxillofac Surg. 2014(42): e29-e32.

63. Functional hemitongue reconstruction  using innervated supraclavicular  fasciocutaneous island flaps with the cervical plexus and reinnervated supraclavicular fasciocutaneous island flaps with neurorrhaphy of the cervical plexus and lingual nerve. Head Neck. 2014;36(1):66-70.

62. Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue,  OK-432, and bleomycin. Br J Oral Maxillofac Surg. 2013;51(8):786-8.

61. Functional Reconstruction With an Extended Supraclavicular Fasciocutaneous Island Flap Following Ablation of Advanced Oropharyngeal Cancer. J Craniofac Surg. 2012;23(6):1668-71.

60. Closure of large oropharyngocutaneous fistulas using a folded extensive supraclavicular fasciocutaneous island flap J Oral Maxillofac Surg Med Pathol,2012.09.012 ARTICLE IN PRESS

59. Contralateral Full-thickness Retroangular Flap for the Reconstruction of Midfacial Through-and-through Defects Following Skin Cancer Ablation. Chin J Dent Res. 2012;15(1):21-4.

58. Extracapsular dissection of pleomorphic adenoma of the parotid gland through minimal preauricular and retroauricular incisions in children. J Craniofac Surg. 2012;23(3):661-3.

57. IMP3 Is a Novel Biomarker to Predict Metastasis and Prognosis of Tongue Squamous Cell Carcinoma. J Craniofac Surg. 2011;22(6):2022-5.

55. Double mental neurovascular v-y island advancement flaps combined with tongue flaps for functionally reconstructing total lower-lip defects. J Craniofac Surg. 2012;23(1):181-3.

54. A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci. 2011;3(4):180-91.

53. Reconstruction of Major Full Cheek Defects With Combined Extensive Pedicled Supraclavicular Fasciocutaneous Island Flaps and Extended Vertical Lower Trapezius Island Myocutaneous Flaps After Ablation of Advanced Oral Cancer. J Oral Maxillofac Surg. 2012;70(5):1224-31.

52. SMAS fold flap and allograft dermal matrix repairing parotid bed following parotidectomy to prevent facial deformity and Frey's syndrome. Asian J Oral Maxillofac Surg. 2012, 24(1):18-22

51. Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(2):228-36.

50. Preliminary Experiences in Treating Infantile Hemangioma With Propranolol. Ann Plast Surg.  2014;72(2):169-72.

49. Maxillary Functional Reconstruction Using a Reverse Facial Artery–Submental Artery Mandibular Osteomuscular Flap with Dental Implants. J Oral Maxillofac Surg, 2011;69(11):2909-14.

48. Expression of Cyr61 in primary salivary adenoid cystic carcinoma and its relation to Ki-67 and prognosis. Oral Oncol. 2011;47(5):365-70.

47. Efficacy survey of swallowing function and quality of life in response to therapeutic intervention following rehabilitation treatment in dysphagic tongue cancer patients. Eur J Oncol Nurs. 2012;16(1):54-8.

46. Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(1):96-104.

45. Percutaneous sclerotherapy of massive macrocystic lymphatic malformations of the face and neck using fibrin glue with OK-432 and bleomycin. Int J Oral Maxillofac Surg. 2011;40(6):572-6.

44. Concerns about anesthetizing palatal tissues. J Oral Maxillofac Surg. 2011;69(2):574.

43. Mandible reconstructed with mandibular osteomuscular and facial-cervico-pectoral flap. Asian J Oral Maxillofac Surg. 2011;(23):69-72

42. Use of the contralateral retroangular island flap for reconstructing midfacial defects after skin cancer ablation. Head Neck. 2011;33(12):1765-8.

41. Reverse facial artery-submental artery deepithelialised submental island flap to reconstruct maxillary defects following cancer ablation. J Craniomaxillofac Surg. 2011;39(7):499-502.

40. Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density. J Craniofac Surg. 2010;21(6):1855-60.

39. Extended supraclavicular fasciocutaneous island flap based on the transverse cervical artery for head and neck reconstruction after cancer ablation. J Oral Maxillofac Surg. 2010;68(10):2422-30.

38. A pedicled mandibular osteomuscular flap for reconstructing composite mandibular defects. Oral Surg. 2010;3(1):16-21.

37. Reconstruction of large defects of the neck using an extended vertical lower trapezius island myocutaneous flap following salvage surgery for neck recurrence of oral carcinoma. J Plast Reconstr Aesthet Surg. 2011;64(3):319-22.

36. Reverse facial-submental artery island flap for reconstruction of oropharyngeal defects following middle and advanced-stage carcinoma ablation. Br J Oral Maxillofac Surg. 2011;49(3):194-7

35. The feasibility of facial-submental artery island myocutaneous flaps for reconstructing defects of the oral floor following cancer ablation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(6):e12-6.

34. Percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin. Int J Pediatr Otorhinolaryngol. 2010;74(4):422-425.

33. Chen WL, et al. Facial Contour Reconstruction After Benign Tumor Ablation Using Reverse Facial-Submental Artery Deepithelialized Submental Island Flaps. J Craniofac Surg. 2010;21(1):83-86.

32. Reverse facial-submental artery island flap for the reconstruction of maxillary defects after cancer ablation. J Craniofac Surg. 2009;20(6):2217-20

31. Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):e89-93.

30. Percutaneous sclerotherapy of massive venous malformations of the face and neck using fibrin glue combined with OK-432 and pingyangmycin. Head Neck. 2010,32(4):467-472.

29. Prognostic significance of erythropoietin and erythropoietin receptor in tongue squamous cell carcinoma. Br J Oral Maxillofac Surg. Br J Oral Maxillofac Surg. 2009;47(6):470-5.

28. Submental flap for reconstructing tongue defect with V-Y advancement flap for repairing submental defect. Otolaryngol Head Neck Surg. 2009;141(2):202-206.

27. A multidisciplinary approach to treating maxillofacial arteriovenous malformations in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(1):41-47.

26. Surgical excision of cervicofacial giant macrocystic lymphatic malformations in infants and children. Int J Pediatr Otorhinolaryngol. 2009;73(6):833-7.

25. Inhibition of VEGF expression in tongue squamous cancer cells via RNA interference silencing of iNOS gene. Int J Oral Maxillofac Surg. 2009,38(4):369-373.

24. Pediatric Mandibular Reconstruction After Benign Tumor Ablation Using a Vascularized Fibular Flap. J Craniofac Surg. 2009,20(2):431-434

23. The trapezius osteomyocutaneous island flap for reconstructing hemimandibular and oral defects following the ablation of advanced oral malignant tumors. J Craniomaxillofac Surg. 2009,37(2):91-95.

22. Transplantation of a reverse facial artery pedicled submandibular gland in a dog. Int J Oral Maxillofac Surg. 2008;37(11):1054-8.

21. Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benign tumors. Head Neck. 2009,31(6):725-731.

20. Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009,107(3): 359-363

19. Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy. Ann Plast Surg.2009;62(2):154-7

18. Removal of second branchial cleft cysts using a retroauricular approach. Head Neck. 2009;31(5):695-698.

17. Expression of Inducible Nitric Oxide Synthase and Vascular Endothelial Growth Factor in Ameloblastoma. J Craniofac Surg. 2009;20(1):171-175.

16. Reconstruction with Extended Vertical Lower Trapezius Island Myocutaneous Flap for Total Glossectomy. Chin J Dental Research, 2008,11(1),42-46.

15. Removal of the submandibular gland using a combined retroauricular and transoral approach. J Oral Maxillofac Surg. 2009;67(3):522-7.

14. SMAS fold flap and ADM repair of the parotid bed following removal of   parotid haemangiomas via pre- and retroauricular incisions to improve cosmetic outcome and prevent Frey's syndrome. J Plast Reconstr Aesthet Surg. 2008;61(8):893-898.

13. Effect of using RNA interference to alter iNOS gene expression on the proliferation of tongue squamous cell carcinoma cell line Tca8113. Br J Oral Maxillofac Surg. 2008,46(6):435-438.

12. Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(2):254-257.

11. Reconstruction of the tongue using an extended vertical lower trapezius island myocutaneous flap after removal of advanced tongue cancer. Br J Oral Maxillofac Surg. 2008,46(5):379-382.

10. Two submental island flaps for reconstructing oral and maxillofacial defects following cancer ablation. J Oral Maxillofac Surg. 2008;66(6):1145-56.

9. Extended vertical lower trapezius island myocutaneous flap for repairing extensive oropharyngeal defects. J Oral Maxillofac Surg. 2009;67(6):1349-53.

8. A pilot study on combination compartmentalization and sclerotherapy for the treatment of massive venous malformations of the face and neck. J Plast Reconstr Aesthet Surg. 2008;61(12):1486-92.

7. Pedicled Mandibular Osteomuscular Flap for Zygomatic Reconstruction through a Modified Weber-Ferguson Incision. J Craniofac Surg. 2008; 19(1):235-240.

6. Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. Int J Oral Maxillofac Surg. 2007;36(6):541-4.

5. Extended vertical lower trapezius island myocutaneous flap in reconstruction of oral and maxillofacial defects after salvage surgery for recurrent oral carcinoma. J Oral Maxillofac Surg. 2007, 65(2):205-11.

4. Reconstruction of full cheek defects with combined temporalis myofacial flaps and  facial-cervico-pectroral flaps. Oral Surg Oral Med, Oral Pathol Oral Radiol Endod. 2007, 103(1): e10-e15.

3. Extended vertical lower trapezius lsland myocutaneous flap for reconstruction of cranio-maxillofacial defects. Int J Oral Maxillofac Surg. 2007, 36(2):165-70.

2. Recurrent ameloblastoma of the anterior skull base: three cases treated by radical resections. J Craniomaxillofac Surg. 2006;34(7):412-4.

1. Comprehensive treatment of arteriovenous malformations in the oral and maxillofacial region. J Oral Maxillofac Surg, 2005,63(10):1484-1488 0278-2391.